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目的:奥沙利铂(OXA)与香菇多糖联合治疗恶性腹水的临床疗效和毒副反应。方法:将资料分为A、B组两组,其中A组常规行腹腔穿刺术,术前将香菇多糖及奥沙利铂分别溶于生理盐水10ml中,然后腹腔内依次注入地塞米松10mg,利多卡因10ml,香菇多糖1mg,奥沙利铂(OXA)100mg,注药后嘱患者变换体位,以使药物与腹腔充分接触。上述治疗每周1次,最多3次。治疗前与结束后第1周、4周均测量腹围,行B超检查评价疗效。B组为对照组,腹腔穿刺术,然后腹腔内依次注入地塞米松10mg,利多卡因10ml,香菇多糖1mg,A、B两组均于治疗前与结束后第1周、4周测量腹围,行B超检查评价疗效。结果:共40例患者,A组24例,B组16例,其中A组CR 3例,PR 17例,SD 2例,PD 2例,有效率为(CR+PR)83.3%。B组CR1例,PR5例,SD2例,PD8例,有效率37.5%。结论:奥沙利铂与香菇多糖联合治疗恶性腹水疗效确切,且毒副作用轻,值得临床推广使用。单用香菇多糖疗效有限。
Objective: The clinical efficacy and side effects of oxaliplatin (OXA) and lentinan in the treatment of malignant ascites. Methods: The data were divided into two groups: group A and group B, in which group A was routinely performed abdominal paracentesis. Before operation, lentinan and oxaliplatin were respectively dissolved in 10 ml of normal saline, then dexamethasone 10 mg, Lidocaine 10ml, lentinan 1mg, oxaliplatin (OXA) 100mg, after injection of Zhu Huanzhe change position, so that drugs and abdominal full access. The treatment once a week, up to 3 times. Before treatment and after the end of the first week, 4 weeks were measured abdominal circumference, line B ultrasound examination evaluation of efficacy. Group B was the control group, abdominal paracentesis, followed by intraperitoneal injection of dexamethasone 10mg, lidocaine 10ml, lentinan 1mg, A, B both before and after treatment in the first week, 4 weeks after the measurement of abdominal circumference , Line B ultrasound examination evaluation of efficacy. Results: There were 40 patients in group A, 24 in group B and 16 in group B. There were 3 patients with CR in CR group, 17 patients in PR group, 2 patients in SD group and 2 patients in PD group. The effective rate was (CR + PR) 83.3%. B group CR1 cases, PR5 cases, SD2 cases, PD8 cases, the effective rate was 37.5%. Conclusion: The combination of oxaliplatin and lentinan is effective in the treatment of malignant ascites, and it has light toxicity and side effects. It is worth to be used clinically. Lentinan alone with limited efficacy.