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目的探讨血尿酸升高与冠状动脉粥样硬化的关系。方法行冠状动脉造影病例303例,狭窄50%或以上为阳性病变,其中左前降支、左回旋支、右冠状动脉均有病变者118例,2支冠状动脉病变者90例,1支冠状动脉病变者95例。入院后第2天早晨空腹测血尿酸,血尿酸的测定采用酶法。对血尿酸≥400μmol/L患者的发生率进行统计分析。结果 3支冠状动脉均有病变者118例,血尿酸≥400μmol/L发生率为48.3%;2支冠状动脉病变者90例,血尿酸≥400μmol/L发生率为31.1%;1支冠状动脉病变者95例,血尿酸≥400μmol/L发生率为29.5%。3支冠状动脉病变血尿酸≥400μmol/L的发生率明显高于2支及1支冠状动脉病变者(P<0.05,P<0.01)。结论血尿酸升高与冠状动脉病变具有相关性。对冠心病患者进行血尿酸测定可预测冠状动脉病变的严重性。
Objective To investigate the relationship between elevated serum uric acid and coronary atherosclerosis. Methods There were 303 cases of coronary angiography and 50% or more of them were stenosis. Among them, 118 cases had lesions of left anterior descending branch, left circumflex branch and right coronary artery, 90 cases of 2 coronary artery lesions, 1 coronary artery 95 cases of lesions. On the second day after admission, fasting serum uric acid and uric acid were measured by enzymatic method. The incidence of patients with serum uric acid ≥400μmol / L were statistically analyzed. Results The lesions of all 3 coronary arteries were 118 and the rate of serum uric acid ≥400μmol / L was 48.3%. The incidence of 2 coronary artery lesions was 90 and the incidence of uric acid ≥400μmol / L was 31.1%. One coronary artery disease 95 cases, the incidence of serum uric acid ≥400μmol / L was 29.5%. The incidence of blood uric acid≥400μmol / L in 3 patients with coronary artery disease was significantly higher than that in 2 patients with 1 coronary artery disease (P <0.05, P <0.01). Conclusion The elevated serum uric acid is correlated with coronary artery disease. Determination of uric acid in patients with coronary heart disease can predict the severity of coronary artery disease.