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检测致癌物的DNA加合物有望成为暴露人群的接触指标。主要检测方法有~(32)P-后标记、免疫学、扫描荧光光谱和质谱等。本文用~(32)P-后标记技术对61位铸造工致癌物DNA加合物水平进行了剂量-反应关系的队列研究。血样来自芬兰铸铁厂中61名接触多环芳烃(PAH)的健康工人志愿者,根据他们接触车间空气PAH中所含苯并芘[B(a)P]的高低,将他们分为高接触[>0.2μgB(a)P/m~2]、中接触[0.05～0.2 μgB(a)P/m~2]和低接触[<0.05μgB(a)P/m~3]组;19份对照样品来自芬兰各地无PAH接触史的人群。询问所有受试者的当前吸烟量(每天多少支)。取抗凝血20～50
DNA adducts that detect carcinogens are expected to be indicators of exposure in exposed populations. The main detection methods are ~ (32) P-post-labeling, immunology, scanning fluorescence spectrometry and mass spectrometry. In this paper, a cohort study was conducted on the dose-response relationship of 61 castor carcinogen DNA adducts using ~ (32) P-post-labeling. Blood samples were obtained from 61 workers in the Finnish cast iron factory who were exposed to PAH and divided into high-exposure [B (a) P] groups based on the level of benzopyrene [B (a) P] > 0.2μgB (a) P / m ~ 2], medium exposure [0.05-0.2 μgB (a) P / m ~ 2] and low exposure Samples from all over Finland have no history of PAH exposure. Inquire about the current smoking amount (how many per day) for all subjects. Take anticoagulant 20 ~ 50