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目的 探讨总胆红素 /白蛋白比值 (B/A)与脑干听觉诱发电位 (ABR)的关系及在预测胆红素神经毒性中的价值。方法 将 43例足月非溶血性高胆红素血症患儿 ,根据ABR表现分成A、B、C三组 ,比较三组患儿血清总胆红素 (TBC)、B/A的变化 ,分析B/A与ABR的相关性。结果 与A、B两组比较 ,C组TBC及B/A比值均明显升高 (P <0 0 5 ,P <0 0 1) ,B/A比值与ABR异常密切相关 (χ2 =7 76 ,P <0 0 5 )。结论 B/A比值是预测胆红素脑病的良好指标 ,对于足月高胆患儿B/A比值 >5 0× 10 -3 者应采取积极的治疗措施。
Objective To investigate the relationship between total bilirubin / albumin ratio (B / A) and brainstem auditory evoked potential (ABR) and its value in predicting neurotoxicity of bilirubin. Methods 43 children with non-hemolytic hyperbilirubinaemia were divided into A, B and C groups according to their ABR manifestations. The changes of serum total bilirubin (TBC) and B / A were compared among the three groups. Analysis of B / A and ABR correlation. Results Compared with group A and group B, the ratios of TBC and B / A in group C were significantly increased (P <0.05, P <0.01). The ratio of B / A was closely related to ABR (χ2 = 766, P <0 0 5). Conclusions The B / A ratio is a good indicator for predicting bilirubin encephalopathy. Positive treatment should be taken for patients with full-bodied children with B / A ratio> 50 × 10-3.