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目的探讨母细胞型套细胞淋巴瘤(BV_MCL)的病理特征、免疫表型、诊断和鉴别诊断。方法对2例BV-MCL行HE和免疫组化染色观察。结果1例为经典型母细胞型,肿瘤细胞弥漫、中等偏大、染色质细,核分裂87个/10 HPF;另1例为多形型母细胞型,肿瘤细胞弥漫、多形,中等大的细胞与大细胞混杂,核染色质粗,可见明显的核仁,核分裂36个/10 HPF。2例均cyclinD1(+)。结论BV-MCL少见,是MCL的一种变型,其病理形态和免疫表型特殊,需要与弥漫性大B细胞淋巴瘤、前驱B淋巴母细胞白血病/淋巴瘤等鉴别。
Objective To investigate the pathological features, immunophenotype, diagnosis and differential diagnosis of B cell type mantle cell lymphoma (BV_MCL). Methods Two cases of BV-MCL were observed by HE and immunohistochemistry. Results One case was a classic type of mother cell. The tumor cells were diffuse, moderately large, with fine chromatin and mitotic nucleus 87/10 HPF. The other was polymorphic mother cell type. The tumor cells were diffuse, pleomorphic, moderately large Cells mixed with large cells, nuclear chromatin thick, visible nucleoli, mitotic 36/10 HPF. 2 cases were cyclinD1 (+). Conclusions BV-MCL is a rare type of MCL. Its pathological morphology and immunophenotype are special and need to be distinguished from diffuse large B-cell lymphoma and precancerous B-cell lymphoblastic leukemia / lymphoma.