Neoadjuvant peptide receptor radionuclide therapy for an inoperable neuroendocrine pancreatic tumor

• 作 者: Daniel Kaemmerer Vikas Prasad Wolfgang Daffner Dieter Hrsch Günter Klppel Merten Hommann Richard P Baum
• 机 构: Department of General and Visceral Surgery,Zentralklinik Bad Berka,Department of Nuclear Medicine,Ce
• 出 处: World Journal of Gastroenterology
• 发表日期: 2009年46期
• 关键词: neuroendocrine subsequent endocrine neoplasms neoadjuvant neoplasm initially pal

Pancreatic endocrine tumors are rare but are among the most common neuroendocrine neoplasms of the abdomen.At diagnosis many of them are already advanced and diff icult to treat.We report on an initially inoperable malignant pancreatic endocrine tumor in a 33-year-old woman,who received neoadjuvant peptide receptor radionuclide therapy(PRRT)as firstline treatment.This resulted in a signif icant downstaging of the tumor and allowed its subsequent complete surgical removal.Follow-up for eighteen months revealed a complete remission.This is the first report on neoadjuvant PRRT in a neuroendocrine neoplasm with subsequent successful complete resection.

Pancreatic endocrine tumors are rare but are among the most common neuroendocrine neoplasms of the abdomen. At diagnosis many of them are already advanced and difficult to treat. We report on initially initially operable in malignant pancreatic endocrine tumor in a 33-year-old woman, who received neoadjuvant peptide receptor radionuclide therapy (PRRT) as firstline treatment. his resulted in a signif icant downstaging of the tumor and allowed its subsequent complete surgical removal. Focus-up for eighteen months revealed a complete remission. This is the first report on neoadjuvant PRRT in a neuroendocrine neoplasm with subsequent successful complete resection.