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目的:探讨血清胱抑素C(CysC)对2型糖尿病肾病的临床诊断价值。方法:随机收集2型糖尿病住院患者49例,将患者分为单纯2型糖尿病组(26例)和糖尿病并发肾病组(23例),另设正常对照组(32例)。采用乳胶颗粒增强免疫透射比浊法测定血清CysC的浓度,并与24h尿白蛋白做相关性分析。结果:糖尿病并发肾病组和单纯2型糖尿病组CysC显著高于对照组,差异有统计学意义(P<0.05);糖尿病并发肾病组的CysC和24h白蛋白显著高于单纯2型糖尿病组,差异有统计学意义(P<0.05)。糖尿病并发肾病组中,中晚期肾病亚组的CysC和24h尿白蛋白显著高于早期肾病亚组,相关性分析显示,CysC与24h尿白蛋白呈正相关(r=0.751,P=0.000)。结论:血清CysC水平对糖尿病肾病的诊断有重要价值,血中CysC的浓度可作为反映糖尿病肾病患者肾损害的良好指标。
Objective: To investigate the clinical value of serum cystatin C (CysC) in the diagnosis of type 2 diabetic nephropathy. Methods: Forty-nine inpatients with type 2 diabetes mellitus were randomized into two groups: type 2 diabetes mellitus (n = 26) and diabetic nephropathy (n = 23), and a normal control group (n = 32). Serum CysC concentration was measured by latex particle-enhanced immunoturbidimetry and correlation analysis with 24 h urinary albumin. Results: The CysC in diabetic nephropathy group and simple type 2 diabetes group were significantly higher than those in control group (P <0.05). The levels of CysC and 24h albumin in diabetic nephropathy group were significantly higher than those in simple type 2 diabetes group There was statistical significance (P <0.05). In diabetic nephropathy group, the levels of CysC and 24h urinary albumin in patients with advanced nephropathy were significantly higher than those in patients with early nephropathy. Correlation analysis showed that there was a positive correlation between CysC and urinary albumin 24h (r = 0.751, P = 0.000). Conclusion: The serum CysC level is of great value in the diagnosis of diabetic nephropathy. The concentration of CysC in blood can be used as a good indicator of renal damage in patients with diabetic nephropathy.