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以大剂量城市悬浮颗粒物(SP)经气管染毒叙利亚仓鼠,并追踪观察其肺损伤变化。仓鼠染毒SP 15mg/kg后3及6个月,肺灌洗液(BAL)的细胞和生化组成与对照组相比无显著差别。染毒后6个月肺羟脯氨酸含量显著增加,肺间质成纤维细胞增生和胶原纤维沉积,表明肺间质有轻度纤维组织增生。根据本实验结果采用Sanders公式进行初步估计,如城市SP不超过现有国家标准,人在10年中所吸入的SP总量尚低于可能引起肺纤维组织增生的剂量。
Syrian hamsters were tracheotomized with large doses of urban suspended particulates (SP), and their lung injury changes were observed. At 3 and 6 months after hamster exposure to SP 15 mg / kg, there was no significant difference in cell and biochemical composition of lung lavage fluid (BAL) compared with the control group. Lung hydroxyproline content was significantly increased 6 months after exposure to pulmonary interstitial fibroblast proliferation and collagen fiber deposition, suggesting that there is mild fibrosis in the lung interstitium. According to the results of this experiment, the Sanders formula was used to make a preliminary estimation. For example, if the city SP does not exceed the existing national standards, the total amount of SP inhaled by humans in 10 years is still below the dose that may cause pulmonary fibrosis.