论文部分内容阅读
目的探讨短程唑来膦酸联合局部放疗治疗恶性肿瘤骨转移的临床疗效。方法 31例骨转移癌患者随机分为两组,联合治疗组16例,采用唑来膦酸加局部放疗;单纯放疗组15例。结果联合治疗组和单纯放疗组镇痛效果分别为93.8%和80.0%,差异有统计学意义(P<0.05);联合治疗组活动能力、生存质量的提高率及骨质修复有效率分别为87.5%、75.0%、43.8%,与单纯放疗组相比,差异均有统计学意义(P<0.05)。结论短程唑来膦酸联合放疗治疗恶性肿瘤骨转移疗效确切,可有效控制骨痛,改善患者的活动能力、生存质量并增加骨质修复。
Objective To investigate the clinical efficacy of zoledronic acid combined with local radiotherapy in the treatment of bone metastases of malignant tumors. Methods Twenty-one patients with metastatic bone cancer were randomly divided into two groups. The combination therapy group (n = 16) was treated with zoledronic acid plus local radiotherapy and the radiotherapy alone group (n = 15). Results The analgesic effects of the combination therapy group and the radiotherapy alone group were 93.8% and 80.0%, respectively, with significant differences (P <0.05). The activity, quality of life improvement rate and effective rate of bone repair in the combination therapy group were 87.5 %, 75.0%, 43.8%, respectively, compared with radiotherapy alone group, the difference was statistically significant (P <0.05). Conclusions Short-term zoledronic acid combined with radiotherapy is effective in treating malignant bone metastases, which can effectively control bone pain, improve patient’s mobility, quality of life and increase bone repair.