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抑素(inhibin)是由卵巢颗粒细胞或睾丸支持细胞分泌的一种糖蛋白激素,它对垂体促性腺激素具有负反馈调节作用,亚胺环己酮(cycloheximide)是一种蛋白质生物合成的强抑制剂。为了研究抑素的作用机制,作者比较了抑素(32KDa,从猪卵泡液提取)和亚胺环己酮分别对离体培养的大鼠腺垂体细胞合成与分泌促性腺激素的作用,结果表明:(1)抑素和亚胺环己酮都能抑制腺垂体卵泡刺激素(FSH)的基础分泌及细胞内 FSH 含量(ED_(50)分别为1.0ng/ml 和22.5ng/ml),但它们都不改变黄体生成素(LH)的基础分泌及细胞
Inhibin, a glycoprotein hormone secreted by ovarian granulosa cells or supporting cells of the testis, has a negative feedback regulation on pituitary gonadotropin. It is a protein that has a strong biosynthesis Inhibitors. In order to study the mechanism of action of somatostatin, the authors compared the effects of somatostatin (32 kDa, extracted from porcine follicular fluid) and iminocyclohexanone on the synthesis and secretion of gonadotropin in cultured rat pituitary gland cells. The results showed that (1) Both somatostatin and iminocyclohexanone could inhibit the basal secretion and the intracellular FSH content (1.0 ng / ml and 22.5 ng / ml, respectively) of adenohypophyseal follicle stimulating hormone (FSH) None of them alter the basal secretion and cells of luteinizing hormone (LH)