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目的 综合评价针吸细胞学检查，癌细胞ＤＮＡ 含量分析，癌胚抗原检测和乳腺钼靶片在诊断乳腺癌中的作用；探讨４ 项指标联合诊断的准确性和重要意义。方法 随机选择１５７ 例乳腺肿块或乳头溢液的患者，术前均行针吸细胞学、ＤＮＡ含量、癌胚抗原及双乳钼靶片检查，并和术后病理相对照。结果 针吸细胞学检查诊断符合率最高，为８５ ．３５ ％ ；流式细胞术测定细胞ＤＮＡ 含量的假阳性率最高，为３４ ．２０ ％ ；钼靶Ｘ 摄片的假阴性率最高，为４４．５４ ％ ；而４ 项指标联合诊断使乳腺癌诊断符合率提高到９２ ．３５ ％ （ Ｐ ＜ ０ ．０５） ，假阳性率降至１ ．９６ ％ （ Ｐ ＜０ ．０５），假阴性率降至５．９３ ％（ Ｐ＜ ０．０１）。结论４ 项指标联合诊断可以明显提高乳腺癌的正确诊断率，并有助于早期诊断。
OBJECTIVE: To evaluate the accuracy and significance of needle aspiration cytology, analysis of DNA content in cancer cells, detection of carcinoembryonic antigen and breast molybdenum target in the diagnosis of breast cancer. Methods A total of 157 patients with breast lumps or nipple discharge were randomly selected. Needle aspiration cytology, DNA content, carcinoembryonic antigen and molybdenum breast molybdenum target films were performed preoperatively and compared with postoperative pathology. Results needle aspiration cytology diagnosis highest coincidence rate of 85. 35%. The highest false-positive rate of DNA content was 34% by flow cytometry. 20% respectively. The false negative rate of mammography X-ray was the highest (44.54%), while the combination of 4 indicators increased the coincidence rate of breast cancer diagnosis to 92. 35% (P <0 .05), the false positive rate dropped to 1. 96% (P <0.05), and the false negative rate decreased to 5.93% (P <0.01). Conclusions Combined diagnosis of four indicators can significantly improve the correct diagnosis of breast cancer, and help early diagnosis.