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肺癌是最常见的恶性肿瘤之一,目前已成为第一位危害男性健康的恶性肿瘤。肺癌易发生浸润转移,其5年生存率远低于其它恶性肿瘤,临床治疗效果及预后均欠佳。因此,研究肺癌的病因及浸润转移机制对其治疗和预后有着重要的临床意义。传统观点认为吸烟是肺癌最重要的高危因素,烟草中化学物质可损伤支气管上皮细胞,导致癌基因激活和抑癌基因失活,进而引起细胞的癌变转化。然而,越
Lung cancer is one of the most common malignancies and has become the first malignant tumor to endanger men’s health. Lung cancer prone to invasion and metastasis, its 5-year survival rate is much lower than other malignancies, clinical treatment and prognosis are poor. Therefore, the study of the etiology of lung cancer and invasion and metastasis mechanism of its treatment and prognosis has important clinical significance. The traditional view that smoking is the most important risk factor for lung cancer, tobacco chemicals can damage the bronchial epithelial cells, leading to activation of oncogenes and tumor suppressor gene inactivation, and then cause cancer cells into transformation. However, the more