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目的 探讨心包液肿瘤标记物检测对癌性心包积液的诊断价值。方法 采用放免法，测定经临床确诊的１７ 例转移性癌性心包积液和１５ 例良性心包积液中ＣＥＡ、ＣＡ１９９ 、ＣＡ５０含量，并予分析。结果 癌性心包液中ＣＥＡ、ＣＡ１９９ 、ＣＡ５０ 含量较良性心包液显著增高。各标记物在癌性心包液增高的阳性率均为７６－４７ ％ ，特异性为９６－８８ ％ 。ＣＥＡ 加ＣＡ１９９ 或ＣＡ５０ 联检，单项阳性率提高为８８－２４％ ，但特异性降为９３－７５ ％ 。若上述联检中多项标记物均阳性，对癌性心包液诊断的特异性可达１００％ ，但敏感性降为６４－７１％ 。结论 心包液ＣＥＡ、ＣＡ１９９ 、ＣＡ５０ 检测，可作为癌性心包积液诊断的重要依据。
Objective To investigate the diagnostic value of pericardial fluid tumor markers in the detection of cancerous pericardial effusions. Methods The radioimmunoassay was used to determine the content of CEA, CA199 and CA50 in 17 cases of metastatic pericardial effusion and 15 cases of benign pericardial effusion after clinical diagnosis. Results The content of CEA, CA199 and CA50 in cancerous pericardial fluid was significantly higher than that of benign pericardial fluid. The positive rate of each marker in cancerous pericardial fluid was 76-47 % with a specificity of 96-88 %. CEA plus CA19-9 or CA50 co-detection, the single positive rate increased to 88-24%, but the specificity was reduced to 93-75%. If all the above markers are positive, the specificity of diagnosis of cancerous pericardial fluid can reach 100%, but the sensitivity is reduced to 64-71%. Conclusion The detection of pericardial fluid CEA, CA199 and CA50 can be used as an important basis for the diagnosis of cancerous pericardial effusion.