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急性心肌梗塞的正确诊断是一个重要的临床问题,它可决定病人的存活.病人的病史可能无助于诊断,而ECG的改变又不够灵敏,特别是梗塞面积小时更是如此,因此医生就得靠血清酶活性的测定来帮助诊断.研究结果表明,血清GOT(ASAT)、CK及其同工酶与LDH及其同工酶活性的改变,能反映心脏的病理变化.这是因为:①这些酶在心肌组织细胞浆中的活性远比血清中要高;②组织损伤时,胞浆酶即释放入血,而线粒体酶和结合在细胞膜上的酶则释放较难,如心肌损伤时就难得见到线粒体GOT与线粒体CK;③酶从组织中释放后,在
Correct diagnosis of acute myocardial infarction is an important clinical problem that can determine the patient’s survival, the patient’s medical history may not help diagnosis, and ECG changes are not sensitive enough, especially if the infarct size is small, so the doctor will have to Rely on the determination of serum enzyme activity to help diagnose.The results show that serum GOT (ASAT), CK and its isoenzyme and LDH and its isoenzyme activity changes, can reflect the pathological changes of the heart.This is because: ① these Enzyme activity in the myocardial tissue of the cytoplasm is much higher than in serum; ② tissue damage, the release of cytosolic enzymes into the blood, and mitochondrial enzymes and enzymes in the cell membrane is more difficult to release, such as myocardial injury is rare See mitochondrial GOT and mitochondrial CK; ③ enzyme released from the tissue after