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Objective: To evaluate whether preimplantation genetic testing for aneuploidy (PGT-A) with comprehensive chromosome screening increases live birth rate (LBR) in normal karyotype couples with recurrent pregnancy loss (RPL).Methods: A retrospective cohort follow-up study of 506 couples with RPL was conducted between April 2014 and March 2017.Couples were allocated to two groups according to their decision to choose PGT-A or not.The primary outcome was LBR per start/transfer cycle;secondary outcomes were ongoing pregnancy rate and miscarriage rate.Statistical analyses were conducted using univariate and multivariate logistic regression models adjusted for matal age.Results: LBR per start (26.6％ vs.15.4％,relative risk[RR]: 2.66,95％ confidence interval[CI][1.69-4.20],P ＜ 0.0001;adjusted RR[aRR]:2.40,95％ CI[1.49-3.86],P =0.0004) and per transfer (44.9％ vs.25.1％,RR: 3.00,95％ CI[1.96-4.60],P ＜ 0.0001;aRR: 2.64,95％CI[1.68-4.14],P ＜ 0.0001) was significantly higher in the PGT-A group than in the non-PGT-A group.The miscarriage rate was significantly lower in the PGT-A group compared to the non-PGT-A group (15.7％ vs.34.6％,RR: 0.27,95％ CI[0.13-0.57],P =0.00005;aRR: 0.26,95％CI[0.12-0.57],P =0.0007).Conclusions: LBR per start cycle following PGT-A is significantly higher,and risk of miscarriage is significantly lower among infertile couples with RPL,irrespective of matal age.PGT-A should be recommended to infertile couples with RPL.