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目的总结国内首例Rh阴性血型同胞间半相合造血干细胞移植经验。方法对1例53岁慢性粒细胞白血病慢性期女性患者实施同胞间半相合造血干细胞移植(外周血干细胞加骨髓干细胞混合移植),观察造血重建及移植相关并发症。结果患者ANC>0.5×109/L,PLT>20×109/L的时间分别为+15d,+18d;染色体检查提示有XY染色体;+39d内未观察到急性移植物抗宿主病、肝静脉闭塞病、肝肾功能损伤等移植并发症。结论半相合造血干细胞移植可解决供者来源困难,是治疗慢性粒细胞白血病的有效手段。
Objective To summarize the experience of the first Rh-negative blood type sibling haploidentical hematopoietic stem cell transplantation in China. Methods A half-matched sibling hematopoietic stem cell transplantation (peripheral blood stem cells plus bone marrow stem cells mixed transplantation) was performed on a 53-year-old female with chronic myeloid leukemia. The hematopoietic reconstitution and transplantation-related complications were observed. Results The time of patients with ANC> 0.5 × 109 / L and PLT> 20 × 109 / L were + 15d and + 18d respectively. Chromosome examination suggested XY chromosome; acute graft-versus-host disease and hepatic vein occlusion were not observed within 39 days Disease, liver and kidney dysfunction such as transplant complications. Conclusion Hemopharyngeal hematopoietic stem cell transplantation can solve the problem of donor source and is an effective treatment for chronic myeloid leukemia.