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采用ELISA双抗体夹心法检测了20例原发性系膜增生性肾炎（MSPGN）患儿血清及尿IL-6、IL-8活性水平，并分析IL-6、IL-8水平与MsPGN临床及病理改变的关系。结果表明：原发性MSPGN患儿血清及尿IL-6、IL-8水平均增高，尿IL－6、IL－8增高与血清IL-6、IL-8水平无平行关系。尿IL-6、IL-8水平与MSPGN严重蛋白尿的发生及肾小球病变程度呈正相关。研究提示检测血清及尿IL-6、IL-8水平对原发性MsPGN的临床分析具有十分重要的意义。
The levels of IL-6 and IL-8 in serum and urine of 20 children with primary mesangial proliferative glomerulonephritis (MSPGN) were detected by enzyme-linked immunosorbent assay (ELISA). The levels of IL-6, IL- The relationship between pathological changes. The results showed that the levels of IL-6 and IL-8 in serum and urine of children with primary MSPGN were increased, while the levels of urinary IL-6 and IL-8 were not correlated with the serum levels of IL-6 and IL-8. Urine IL-6, IL-8 levels and MSPGN serious proteinuria and glomerular lesions was positively correlated. Research suggests that the detection of serum and urinary IL-6, IL-8 levels of clinical analysis of primary MsPGN is of great significance.