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瘦素具有促进脂肪分解、调节体重作用,但许多肥胖者血清瘦素水平增高,说明存在瘦素抵抗。细胞因子信号转导抑制因子3(suppressor of cytokine signaling-3,SOCS-3)可由瘦素诱导产生,而SOCS-3又可抑制瘦素信号通路。瘦素作用细胞
Leptin promotes lipolysis and regulates body weight, but many obese people have elevated serum leptin levels, indicating that there is leptin resistance. Suppressor of cytokine signaling-3 (SOCS-3) can be induced by leptin, while SOCS-3 can inhibit leptin signaling pathway. Leptin cells