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目的研究酯型儿茶素载体栓对细菌性阴道炎的治疗作用。方法新西兰大白兔分为5组,即模型对照、妇康载体栓及酯型儿茶素低、中、高剂量(29、58、116 mg/kg)组。采用金黄色葡萄球菌和大肠埃希菌的混合菌液直接注入新西兰大白兔阴道内复制成细菌性阴道炎模型,观察酯型儿茶素载体栓对细菌性阴道炎的作用。结果连续7 d阴道局部给药,治疗大白兔细菌性阴道炎,酯型儿茶素载体栓中、高剂量组的疗效与妇康载体栓组相同,治愈率可达83.3%,有效率为100%;细菌学检测,与模型组比较,酯型儿茶素载体栓中、高剂量组和妇康载体栓组均可明显抑制金黄色葡萄球菌和大肠埃希菌的生长(P<0.05)。结论酯型儿茶素载体栓对新西兰大白兔的细菌性阴道炎有明显治疗作用。
Objective To study the therapeutic effect of ester-type catechin carrier plug on bacterial vaginosis. Methods New Zealand white rabbits were divided into five groups: model control, Fukang carrier suppository and ester type catechins low, medium and high dose (29,58,116 mg / kg) group. The mixed bacterial liquid of Staphylococcus aureus and Escherichia coli was directly injected into the vagina of New Zealand white rabbits to replicate into bacterial vaginosis model to observe the effect of ester type catechin carrier plug on bacterial vaginosis. Results The vagina was administered locally for 7 consecutive days to treat bacterial vaginitis in rabbits. The efficacy of ester-type catechin carrier in middle dose and high dose group was the same as that in Fukang carrier suppository group. The cure rate was 83.3% and the effective rate was 100 %. Bacteriological examination showed that compared with the model group, the growth of Escherichia coli and Staphylococcus aureus was significantly inhibited by the ester-type catechin carrier, the high dose group and the Fukang vehicle suppository group (P <0.05). Conclusion Ester-type catechin carrier suppository has a significant therapeutic effect on bacterial vaginosis in New Zealand white rabbits.