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的观察鲨鱼软骨粉对小鼠移植性SRS(淋巴瘤)生长的影响与微血管密度的关系。方法肿瘤称重 ,切片用vWF免疫组化染色及微血管计算机扫描方法半定量。结果在已建立的小鼠SRS实体瘤模型上应用口服鲨鱼软骨粉治疗 ,发现54毫克/d治疗15d后肿瘤重量及微血管密度较对照组明显减少(P<0.05)。治疗组血管内皮生长因子(VEGF)与VEGF受体FIK -1表达明显减少(P<0.05)。结论上述剂量的鲨鱼软骨粉可抑制小鼠移植性SRS的生长。肿瘤微血管形成的抑制可能是鲨鱼软骨粉抗肿瘤机制之一 ,后者又与VEGF和FIK -1表达的抑制有关。
Observation of the effect of shark cartilage powder on the growth of transplanted SRS (lymphoma) in mice and its relationship with microvessel density. Methods The tumors were weighed. The sections were semi-quantitated by vWF immunohistochemical staining and microvascular computer scanning. The results of the application of oral shark cartilage powder in the established mouse SRS solid tumor model showed that the tumor weight and microvessel density after 15 days of 54 mg/d treatment were significantly lower than those in the control group (P<0.05). The expression of vascular endothelial growth factor (VEGF) and VEGF receptor FIK-1 was significantly decreased in the treatment group (P<0.05). Conclusion The above dose of shark cartilage powder can inhibit the growth of transplanted SRS in mice. Inhibition of tumor microvessel formation may be one of the anti-tumor mechanisms of shark cartilage powder, which in turn is associated with inhibition of VEGF and FIK-1 expression.