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采用全价颗粒饲料，辅以定期定量腹腔注射右旋糖酐铁1．0～2．0ml／周（含铁50～100mg／周）的方法建立了高铁对大鼠主要脏器病理损伤的动物模型。实验组和对照组相比，实验组大鼠各主要脏器内含铁量明显高于对照组大鼠（P＜0．05），镜下组织细胞发生了不同程度的病理损伤、细胞变性，影响细胞正常的生理功能。
A complete animal model of high-speed rail injury of major organs of rats was established by using full-price pellet feed supplemented with regular quantitative intraperitoneal injection of iron dextran 1.0-2.0ml / week (iron 50-100mg / week). Compared with the control group, the content of iron in the major organs in the experimental group was significantly higher than that in the control group (P <0.05). The histopathology of the experimental group showed different degree of pathological damage, cell degeneration, Affect the normal physiological function of cells.