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观察25例硬膜外阻滞行剖宫产的正常产妇及胎儿脐血内TXA_2及PGI_2的变化。发现母体在胎儿娩出及术毕时与麻醉前相比,TXA_2及PGI_2均无统计学的改变(P>0.05),胎儿脐血内含量在母体范围内。表明局麻药利多卡因及丁卡因经硬膜外用药后,对TXA_2和PGI_2的平衡无明显影响,可能是由于硬膜外阻滞有效地抑制手术伤害刺激所致的应激反应。
To observe the changes of TXA_2 and PGI_2 in normal pregnant women and fetus with cesarean section in 25 cases of epidural block. The results showed that there was no statistical difference in TXA_2 and PGI_2 between the two groups (P> 0.05). The content of fetal cord blood was within the range of maternal. The results showed that the local anesthetic lidocaine and tetracaine did not affect the balance of TXA_2 and PGI_2 after epidural administration, which may be due to the fact that epidural block effectively restrain the stress response caused by surgical injury stimulation.