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碳-氢键官能团化已经成为化学中最重要的研究课题之一.控制碳-氢键官能团化的区域选择性在目前是最关键的问题,同时也很具有挑战性.过渡金属催化的重氮化合物的有机转化,例如杂-氢键插入、环丙烷化、交叉偶联反应以及烷基碳-氢[C(sp~3)—H]键官能化反应发展比较成熟,但是芳烃的碳-氢[C(sp~2)—H]键官能团化反应研究较少.这篇综述总结了过渡金属催化重氮化合物参与的芳烃的碳-氢[C(sp~2)—H]键官能团化反应研究进展.为了实现反应的选择性,有两种策略运用在其中.一种是导向的碳-氢(C—H)键活化,主要得到邻位碳-氢键官能团化产物;另外一种是非导向策略,主要表现出对位选择性.对一些代表性的例子也做了机理介绍.
Carbon-hydrogen bond functionalization has become one of the most important research topics in chemistry.Controlling the regioselectivities of carbon-hydrogen bond functionalization is the most crucial issue at present and is also very challenging.Transition metal-catalyzed diazotization Organic conversion of compounds, such as hetero-hydrogen insertion, cyclopropanation, cross-coupling reaction and alkyl carbon-hydrogen [C (sp ~ 3) -H] There are few studies on the functionalization of [C (sp ~ 2) -H] bond in the presence of a transition metal catalyst diazotized compound. This review summarizes the functionalization of the carbon-hydrogen [C In order to achieve the selectivity of the reaction, two strategies are applied: one is the directed carbon-hydrogen (C-H) bond activation, which leads to the ortho-carbon-hydrogen bond functionalization product, and the other is non- Oriented strategy, the main show the selectivity, some of the representative examples also made a mechanistic introduction.