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为研究支气管动脉灌注顺铂、阿霉素等联合化疗药物对非小细胞肺癌细胞凋亡的影响。我们选择 1996～ 1998年间在我院接受手术治疗的 40例非小细胞肺癌 ,其中单纯手术切除的 2 0例为对照组 ;术前 2周接受过支气管动脉化疗的2 0例为实验组。应用原位DNA断端标记法检测两组标本的癌细胞凋亡水平。结果 :两组间凋亡指数以及两组间鳞癌凋亡指数比较有显著性差异 (P <0 .0 5 ) ;两组间腺癌凋亡指数以及两组内鳞癌和腺癌间凋亡指数比较无统计学意义 (P >0 .0 5 )。结论 :支气管动脉灌注顺铂、阿霉素等联合化疗药物能诱导非小细胞肺癌细胞凋亡。
To study the effect of bronchial arterial infusion of cisplatin, doxorubicin and other chemotherapy drugs on the apoptosis of non-small cell lung cancer cells. We selected 40 cases of non-small cell lung cancer that were surgically treated in our hospital from 1996 to 1998. Twenty patients who had undergone surgical resection were the control group. Twenty patients who received bronchial artery chemotherapy two weeks before surgery were the experimental group. The in situ DNA fragmentation method was used to detect the apoptosis of cancer cells in both groups. Results: There was a significant difference in the apoptotic index between the two groups and the apoptotic index of squamous cell carcinoma between the two groups (P < 0.05). The apoptotic index of adenocarcinoma between the two groups and the squamous cell carcinoma and adenocarcinoma between the two groups. The death index was not statistically significant (P > 0.05). Conclusion : Bronchial arterial infusion of cisplatin and doxorubicin combined with chemotherapeutic drugs can induce apoptosis of non-small cell lung cancer cells.