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目的研究７０３－Ⅱ注射液对肠系膜微循环的作用。方法采用活体肠系膜微循环观察方法，结合血液粘度测量，共观察了氢溴酸樟柳碱、７０３－Ⅱ注射液、盐酸奴夫卡因三种药物对肠系膜微循环的影响。实验用大鼠按常规方法麻醉，然后以静脉注射给药，分别于药后１、５、１５、３０、６０、１２０ｍｉｎ在显微镜下观察大鼠肠系膜微血管管径、血流速度、流态等的变化。结果发现给药后３０～１２０ｍｉｎ，樟柳碱对肠系膜微动脉有一定扩张作用，而７０３－Ⅱ注射液对血管管径的作用不明显。奴夫卡因给药后１ｍｉｎ对肠系膜微动、静脉有一过性的收缩，而后舒张，血流减慢。注射生理盐水对血管管径及血流状态无明显改变。血液粘度测定显示樟柳碱、奴夫卡因对血液粘度改变不明显。结论７０３－Ⅱ注射液有显著降低血液粘度的作用。
Objective To study the effect of 703-Ⅱ injection on mesenteric microcirculation. Methods In vivo mesenteric microcirculation observation and blood viscosity measurement were used to observe the effects of three kinds of drugs, anisodine hydrobromide, 703-Ⅱ injection and nuvone hydrochloride on mesenteric microcirculation. Experimental rats were anesthetized by conventional methods and then administered by intravenous injection. The diameters of mesentery capillaries, blood flow velocity, fluid state, etc. were observed under microscope at 1, 5, 15, 30, 60 and 120 minutes after treatment Variety. The results showed that 30 ~ 120min after administration, anisodine on mesenteric arterioles have some expansion, while the effect of 703-Ⅱ injection on vascular diameter is not obvious. Nuvucaine 1min after administration of mesenteric micro-venous, transient transient contraction, and then diastolic, slowed blood flow. Injection of saline on vascular diameter and blood flow status no significant change. Blood viscosity measurement showed anisodine, Nuvucine no significant change in blood viscosity. Conclusion 703-Ⅱ injection can significantly reduce blood viscosity.