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目的 :观察注射用益气复脉联合西医疗法治疗心力衰竭患者的临床疗效。方法 :将90例心力衰竭气阴两虚证患者随机分为研究组与对照组各45例,2组均以常规疗法治疗,研究组给予注射用益气复脉联合盐酸多巴酚丁胺注射液治疗,对照组给予盐酸多巴酚丁胺注射液治疗,以7天为1疗程,观察2疗程。治疗前后测定患者的血浆N末端B型钠尿肽前体(NT-pro BNP)水平,经心脏彩超测定左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD)、左室射血分数(LVEF)、舒张早期二尖瓣血流速度(E)、舒张晚期二尖瓣血流速度(A),并计算E/A比值;统计治疗前后的心功能分级情况,评价临床疗效,观察不良反应发生情况。结果:治疗后,研究组总有效率为93.33%,对照组总有效率为73.33%,2组比较,差异有统计学意义(P<0.05)。2组NT-pro BNP及各项心功能指标值均较治疗前改善(P<0.05),研究组各项指标改善情况均优于对照组(P<0.05)。2组心功能情况均较治疗前改善(P<0.05),研究组心功能改善情况优于对照组(P<0.05)。2组患者均未发生不良反应情况。结论:注射用益气复脉联合西医疗法治疗心力衰竭气阴两虚证可有效改善患者的心力衰竭严重程度及心功能,安全性好。
Objective: To observe the clinical efficacy of injection of Yiqi Fumai combined with western medicine in the treatment of patients with heart failure. Methods: Ninety patients with deficiency of Qi and Yin of heart failure were randomly divided into study group and control group, with 45 cases in each group. Both groups were treated by conventional therapy. The study group was given Yiqi Fumai injection combined with dobutamine hydrochloride injection Treatment, control group given dobutamine hydrochloride injection treatment to 7 days for a course of treatment, observed 2 courses. The levels of plasma N-terminal pro-brain natriuretic peptide (NT-pro BNP) were measured before and after treatment. The left ventricular end systolic diameter (LVESD), left ventricular end diastolic diameter (LVEDD), left ventricular ejection fraction (LVEF), early diastolic mitral flow velocity (E), late diastolic mitral flow velocity (A), and calculate the E / A ratio; statistical treatment before and after the classification of cardiac function, evaluation of clinical efficacy, poor observation Reaction occurred. Results: After treatment, the total effective rate was 93.33% in the study group and 73.33% in the control group. There was significant difference between the two groups (P <0.05). The NT-pro BNP and cardiac function indexes of two groups were improved compared with those before treatment (P <0.05). The improvement of each index of the study group was better than that of the control group (P <0.05). The cardiac function in both groups improved compared with that before treatment (P <0.05). The improvement of cardiac function in the study group was better than that in the control group (P <0.05). No adverse reactions occurred in both groups. Conclusion: The combination of Yiqi Fumai and western medicine for the treatment of Qi and Yin Deficiency Syndrome of heart failure can effectively improve the severity of heart failure and cardiac function and safety of patients.