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本文对浙江省台州地区三种不同地理条件(平原、山区、海岛)的居民群近亲结婚情况进行遗传学调查.三个居民群共调查21070人,已婚夫妇6005对,发现近亲结婚122对.占2.03%.其中山区较高,占5.89%(58/984对),平原与海岛较低,分别为1.39(47/3385对)及1.04%(17/1636对)。其近交系数分别是33.80×10~(-4),7.96×10~(-4),和6.97×10~(-4)。三个地区的近亲结婚类型中以三级亲属最多,占近亲结婚的89.30%.近亲结婚的子女遗传病发病率远远高于非近亲结婚(P<0.01)。三个地区近亲结婚子女的遗传病发病率,山区为5.0%,平原6.6%,海岛5.0%;非近亲结婚子女的遗传病发病率分别为0.5、0.2及0.5%.
In this study, we conducted a genetic survey of the cousins’ marriages in three different geographic conditions (plain, mountainous and island) in Taizhou, Zhejiang Province, including 21070 people, 6005 married couples and 122 inbreeding. Accounting for 2.03%, of which, the mountainous areas were higher, accounting for 5.89% (58/984 pairs), while the plains and islands were lower, with 1.39 (47/3385 pairs) and 1.04% (17/1636 pairs), respectively. The inbreeding coefficients were 33.80 × 10 -4, 7.96 × 10 -4 and 6.97 × 10 -4, respectively. Among the three types of marriage, the third-degree relatives accounted for 89.30% of the kin marriages, while the incidences of genetic diseases of the children married by the kinship were much higher than that of the non-kin (P <0.01). The incidence of genetic diseases among close relatives and married children in three areas was 5.0% in mountainous areas, 6.6% in plain and 5.0% in islands. The prevalence of genetic diseases among non-relatives married children was 0.5, 0.2 and 0.5% respectively.