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目的观察40mg/d阿托伐他汀对预防T2DM患者颈动脉硬化的影响。方法将T2DM合并颈动脉斑块患者随机分为给予40mg/d阿托伐他汀治疗的观察(n=31)组和给予常规剂量阿托伐他汀治疗的对照(n=30)组,分别于治疗前和治疗后12周检测血脂指标、颈动脉斑块情况及内皮功能情况。结果观察组TG、TC、LDL-C、载脂蛋白B水平、颈动脉内-中膜厚度、血管内径和斑块面积均低于对照组(P<0.05);载脂蛋白A-Ⅰ水平以及内皮依赖性血管舒张功能均高于对照组(P<0.05);两组HDL-C比较差异无统计学意义。结论 40mg/d阿托伐他汀有助于改善血脂代谢水平、颈动脉斑块情况以及内皮舒张功能,对于预防T2DM患者颈动脉硬化有积极价值。
Objective To observe the effect of 40mg / d atorvastatin on the prevention of carotid atherosclerosis in patients with T2DM. Methods Patients with T2DM complicated with carotid artery plaque were randomly divided into observation group (n = 31) treated with atorvastatin 40 mg / d and control group (n = 30) treated with conventional dose of atorvastatin, Serum lipids, carotid plaques and endothelial function were measured before and 12 weeks after treatment. Results The levels of TG, TC, LDL-C, apolipoprotein B, carotid intima-media thickness, vascular diameter and plaque area in the observation group were lower than those in the control group (P <0.05) Endothelium-dependent vasodilation was higher than that of the control group (P <0.05). There was no significant difference in HDL-C between the two groups. Conclusions Atorvastatin 40 mg / d can improve blood lipids metabolism, carotid plaque and endothelial relaxation, which is of great value in preventing carotid atherosclerosis in patients with T2DM.