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以抗体的独特型为主构成的免疫网络学说近年来引人注目。有关的研究报告逐年增多,使人们对这方面的认识在不断地深化与更新。这一领域的研究对于阐明机体免疫自稳,免疫性疾病的发病机理、新型疫苗的研制、感染与肿瘤疾病的防治提供了重要的理论与实验依据。本文就有关抗体独特型和免疫网络学说的基本概念及其进展作一扼要介绍。一、抗体独特型的结构基础一般认为,独特型(idiotype,Id)是区别不同Ig分子V区的表型标志。从免疫化
Immune network theory, which is mainly composed of the unique type of antibody, attracts attention in recent years. The relevant research reports have been increasing year by year, so that people’s understanding of this area is constantly deepened and updated. The research in this field provides important theoretical and experimental evidences for clarifying the self-stabilization of immunity, the pathogenesis of immune diseases, the development of new vaccines, the infection and the prevention and treatment of cancer diseases. This article gives a brief introduction to the basic concepts of antibody uniqueness and immune network theory and its progress. First, the structural basis of the unique type of antibody It is generally believed that idiotype (Id) is a phenotypic marker that distinguishes V regions of different Ig molecules. From immunization