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[目的]观察芪归芎芍汤联合弥可保治疗气阴两虚2型糖尿病周围神经病变疗效。[方法]使用随机平行对照方法,将62例住院及门诊患者按就诊顺序号方法简单随机分为两组。对照组30例弥可保,0.5mg/次,3次/d,口服。治疗组32例芪归芎芍汤,黄芪、当归、川芎、赤芍、水蛭、三七、豨莶草、细辛、通草、生地、麦冬、天冬、太子参、地骨皮、知母,水煎500m L,1剂/d,早晚分服;西药治疗同对照组。均连续治疗3个月为1疗程。观测临床症状、体征、血液生化指标(空腹血糖-FPG、餐后2h血糖-2h PG、糖化血红蛋白-Hb A1C)、足部震动感觉阈值(VPT)、TCSS评分、不良反应。连续治疗2疗程,判定疗效。[结果]治疗组显效10例,有效18例,无效4例,总有效率87.50%。对照组显效5例,有效14例,无效11例,总有效率63.33%。治疗组疗效优于对照组(P<0.05)。症状及体征评分两组均有改善(P<0.01),治疗组改善优于对照组(P<0.01);足部震动感觉阈值(VPT)两组均有改善(P<0.01),治疗组改善优于对照组(P<0.01)。[结论]芪归芎芍汤联合弥可保治疗气阴两虚2型糖尿病周围神经病变效果显著,无严重不良反应,值得推广。
[Objective] To observe the curative effect of Qigui Xioniu Shaoyitang and Mi Kebao on type 2 diabetic peripheral neuropathy with deficiency of both qi and yin. [Methods] Using randomized parallel control method, 62 inpatients and outpatients were randomly divided into two groups according to the sequence number of visiting doctor. Control group, 30 cases of can insured, 0.5mg / time, 3 times / d, orally. Astragalus, Angelica, Chuanxiong, Radix Paeoniae Alba, Leech, Panax notoginseng, Asarum, Asarum, habitat, Ophiopogon japonicus, asparagus, heterophylla, Digupi, Anemarrhena asparagus , Decoction 500m L, 1 / d, morning and evening service; western medicine treatment with the control group. Continuous treatment for 3 months for a course of treatment. Clinical symptoms, signs, blood biochemical parameters (fasting blood glucose-FPG, postprandial 2h blood glucose -2h PG, glycosylated hemoglobin-Hb A1C), foot vibration sensation threshold (VPT), TCSS score and adverse reactions were observed. Continuous treatment of 2 courses to determine the efficacy. [Result] In the treatment group, 10 cases were markedly effective, 18 cases were effective, 4 cases were ineffective, and the total effective rate was 87.50%. The control group markedly effective in 5 cases, effective in 14 cases, ineffective in 11 cases, the total effective rate was 63.33%. The treatment group was better than the control group (P <0.05). (P <0.01). The treatment group improved better than the control group (P <0.01). The foot vibration sensory threshold (VPT) improved both groups (P <0.01), the treatment group improved Better than the control group (P <0.01). [Conclusion] The combination of Qigui Xiong Shaoyitang and Mi Kebao in the treatment of peripheral neuropathy of type 2 diabetes mellitus with deficiency of both qi and yin has obvious effect without serious adverse reactions and is worth popularizing.