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目的探讨小剂量瑞舒伐他汀对老年慢性心衰合并房颤患者改善心功能及预防房颤复发的临床疗效。方法选取2013年3月—2014年11月收治的98例老年慢性心衰合并房颤患者,随机分为观察组和对照组,各49例。对照组患者采取常规强心利尿扩血管治疗,观察组患者在对照组基础上,加用小剂量瑞舒伐他汀治疗。结果观察组患者总治愈率为93.87%,对照组患者为83.67%(P<0.05)。观察组与对照组患者治疗后在射血分数(LVEF)、左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD)等方面差异显著(P<0.05)。观察组患者三酰甘油(TG),总胆固醇(TC)及低密度脂蛋白胆固醇(LDL-C)指标低于对照组,高密度脂蛋白胆固醇HDL-C(HDL-C)指标高于对照组(P<0.05)。结论小剂量瑞舒伐他汀对老年慢性心衰合并房颤患者疗效显著,明显改善患者心脏各项指标,无严重不良反应,值得临床上进一步推广应用。
Objective To investigate the clinical efficacy of low-dose rosuvastatin on improving cardiac function and preventing recurrence of atrial fibrillation in elderly patients with chronic heart failure and atrial fibrillation. Methods From March 2013 to November 2014, 98 elderly patients with chronic heart failure and atrial fibrillation were randomly divided into observation group and control group, with 49 cases in each group. Patients in the control group were treated with conventional cardiotomy diuretic vasodilation. Patients in the observation group were treated with low-dose rosuvastatin on the basis of the control group. Results The total cure rate of the observation group was 93.87%, while that of the control group was 83.67% (P <0.05). There were significant differences in LVEF, LVESD and LVEDD between observation group and control group after treatment (P <0.05). The indexes of triglyceride (TG), total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) in the observation group were lower than those in the control group, and the indexes of high-density lipoprotein cholesterol HDL-C (P <0.05). Conclusion Low-dose rosuvastatin has a significant effect on elderly patients with chronic heart failure and atrial fibrillation, significantly improve the cardiac indicators, without serious adverse reactions, and worth further promotion and application in clinic.