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作者研究了人体急性暴露到低气压(5000m)低氧下早期的通气和循环变化。受试者为15名20～30岁的健康男性。减压舱内的气压以5.1kPa/分速度从101.1kPa减到56kPa,舱内温度22℃,温度60％。连续监测了静息未吸氧和吸100％氧条件下的通气和循环参数。结果:①在56kPa即刻,通气量无变化;尽管PaO_2和SaO_2明显降低,但PaCO_2无变化。②30分钟后SaO_2和PaO_2进一步降低,但几乎所有受试者对低氧未出现通气反应。心率增加,动脉收缩压降低,每搏量无变化,每分钟心输出量增加(见附表)。③吸100％氧时,通气量明显降低,收缩压和每搏量增加。结果表明,急性暴露在低气压低氧下通气和循环反应低下。
The authors studied the early aeration and circulation changes in humans exposed to hypoxia (5000 m) hypoxia. The subjects were 15 healthy men aged 20-30 years. The pressure in the decompression chamber was reduced from 101.1 kPa to 56 kPa at 5.1 kPa / minute, the temperature in the cabin was 22 ° C., and the temperature was 60%. Ventilation and cycling parameters at rest without oxygen inhalation and 100% oxygen inhalation were continuously monitored. Results: ① Immediately at 56kPa, there was no change in ventilation; PaCO_2 remained unchanged despite the significant decrease of PaO_2 and SaO_2. ② After 30 minutes, the SaO_2 and PaO_2 decreased further, but almost all the subjects did not show any response to hypoxia. Increased heart rate, reduced systolic arterial pressure, no change in stroke volume, increased cardiac output per minute (see schedule). ③ suction 100% oxygen, the ventilation was significantly reduced systolic blood pressure and stroke volume increased. The results show that acute exposure to low pressure hypoxia, ventilation and circulation reaction is low.