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作者曾证实用皮质激素治疗HBV相关膜性肾病(HBVMN)无显著疗效。为了探讨HBVMN患儿用和不用激素治疗前后,单核细胞,T细胞,B细胞和血清内HBVDNA的差别。作者用Southe(?)点杂交的方法,检测了HBVMN患儿不同时期的HBVDNA,以及血清HBV标志,尿蛋白定量等一系列的变化。病人和方法:为1986.1～1987.11月,退伍军人综合医院经肾活检确诊的24例HBVMN患儿,曾用强地松2mg/Kg/天,标准治疗时间>8周,仍持续肾病综合征和大量蛋白尿,年龄<12岁。这些患儿接受一疗程阿糖腺甙和胸腺因子治疗。阿糖腺甙,15mg/Kg/天。共2周;同时,用胸腺因子,2mg/Kg/天,肌注,6个月。患儿血清HBsAg(一)
The authors have demonstrated no significant effect of corticosteroid treatment of HBV-associated membranous nephropathy (HBVMN). In order to investigate the difference of HBVDNA in mononuclear cells, T cells, B cells and serum before and after HBVMN children with and without hormone treatment. The authors used Southe (?) Point hybridization method to detect HBV DNA in different stages of HBVMN patients, and serum HBV markers, urine protein and a series of quantitative changes. Patients and Methods: From 1986.1 to 1987.11, 24 HBVMN patients diagnosed by renal biopsy at the Veterans General Hospital were treated with prednisone 2mg / Kg / day and standard treatment time> 8 weeks. Nephrotic syndrome and a large number of patients Proteinuria, age <12 years. These children received a course of treatment with glyitoside and thymus. Viganoside, 15 mg / Kg / day. A total of 2 weeks; the same time, with thymus factor, 2mg / Kg / day, intramuscular injection, 6 months. Children with serum HBsAg (a)