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目的探讨p53异构体在肾癌中的表达情况,进而为肾癌的早期诊断和临床治疗提供更多的新思路和新方法。方法选择包头市行开放性肾癌根治术患者的肾癌组织和癌旁正常组织各22例,分析其p53异构体△133p53、△133p53β、△133p53γ、P53β、P53γ的表达情况。结果△133p53、△133p53β、△133p53γ在肾肿瘤组织和肾正常组织中表达率差异无统计学意义(P﹥0.05);p53β在肾肿瘤组织中的表达高于肾正常组织(P﹤0.05);p53γ在肾正常组织中的表达高于肾肿瘤组织(P﹤0.05)。结论本研究表明p53异构体p53β、p53γ在肾癌与癌旁正常组织中的表达有显著性差异,经过进一步研究有望为肾癌的早期诊断和临床治疗提供新思路和新方法。
Objective To investigate the expression of p53 isoforms in renal cell carcinoma and to provide more new ideas and new methods for the early diagnosis and clinical treatment of renal cell carcinoma. Methods Twenty-two cases of renal cell carcinoma and adjacent normal tissue were treated with radical nephrectomy in Baotou City. The expression of p53 isoform 133p53, △ 133p53β, △ 133p53γ, P53β and P53γ were analyzed. Results There was no significant difference in the expression rates of △ 133p53, △ 133p53β, △ 133p53γ in renal tumor tissues and normal renal tissues (P> 0.05). The expression of p53β in renal tumor tissues was higher than that in normal renal tissues (P <0.05). The expression of p53γ in normal renal tissues was higher than that in renal tumors (P <0.05). Conclusions This study shows that the p53 isoforms p53β and p53γ have significant differences in the expression between normal renal cell carcinoma and adjacent normal tissues. After further study, it is expected to provide new ideas and new methods for the early diagnosis and clinical treatment of renal cell carcinoma.