Circular RNAs (circRNAs) are endogenous RNAs with a covalently closed single- stranded transcript. They are a novel class of genomic regulators that are linked to many important development and disease processes and are being pursued as clinical and thera
The mdx mouse is a model of Duchenne muscular dystrophy (DMD), a fatal progres-sive muscle wasting disease caused by dystrophin deficiency, and is used most widely in preclinical studies. Mice with dystrophin deficiency, however, show milder muscle streng
Background : Anoxic brain injuries represent the main determinant of poor outcome after cardiac arrest (CA). Large animal models have been described to investigate new treatments during CA and post- resuscitation phase, but a detailed model that includes
Background : Largely due to incidental detection, asymptomatic pancreatic cystic le-sions (PCLs) have become prevalent in recent years. Among them, intraductal papillary mucinous neoplasm (IPMN) infrequently advances to pancreatic ductal adenocarci-noma (
Background : Porcine pancreatic elastase (PPE) is successfully used to induce abdomi-nal aortic aneurysm (AAA) in mice. However, differences between mouse strains in susceptibility to PPE induction have been reported. Kunming mouse is one of the most freq
Background : The Omicron (B.1.1.529) SARS- COV- 2 variant has raised serious con-cerns because of its unprecedented rapid rate of spreading and the fact that there are 36 mutations in the spike protein. Since the vaccine-i nduced neutralizing antibody tar