【摘 要】
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Background : Anoxic brain injuries represent the main determinant of poor outcome after cardiac arrest (CA). Large animal models have been described to investigate new treatments during CA and post- resuscitation phase, but a detailed model that includes
【机 构】
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Intensive Care Experimental Laboratory,Intensive Care Unit,Erasme Hospital, Brussel,Belgium;Intensiv
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Background : Anoxic brain injuries represent the main determinant of poor outcome after cardiac arrest (CA). Large animal models have been described to investigate new treatments during CA and post- resuscitation phase, but a detailed model that includes extensive neuromonitoring is lacking. Method : Before an electrically-i nduced 10- minute CA and resuscitation, 46 adult pigs underwent neurosurgery for placement of a multifunctional probe (intracranial pres-sure or ICP, tissue oxygen tension or PbtO 2 and cerebral temperature) and a bolt- based technique for the placement and securing of a regional blood flow probe and two sEEG electrodes; two modified cerebral microdialysis (CMD) probes were also inserted in the frontal lobes and accidental misplacement was prevented using a per-forated head support. Result : 42 animals underwent the CA procedure and 41 achieved the return of spon-taneous circulation (ROSC). In 4 cases (8.6％) an adverse event took place during prep-aration, but only in two cases (4.3％) this was related to the neurosurgery. In 6 animals (13.3％) the minor complications that occurred resolved after probe repositioning. Conclusion : Herein we provide a detailed comprehensive neuromonitoring approach in a large animal model of CA that might help future research.
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