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探讨儿童肾病综合征血脂代谢异常的特点及其与肾病临床状态和预后的关系。方法对３０例肾病综合征患儿血清脂类、脂蛋白及载脂蛋白水平追踪观察。结果肾病发作期以ＴＣ和ＬＤＬ－Ｃ水平显著升高为主，其升高幅度与血清白蛋白浓度呈显著负相关（ｒ＝－０．５５，Ｐ＜０．０５；ｒ＝－０．６１，Ｐ＜０．０１），伴有ＶＬＤＬ－Ｃ、ＴＧ、ａｐｏ－Ｂ１００升高，ＬＤＬ－Ｃ无明显变化。激素治疗８周后激素敏感型患儿ＨＤＬ－Ｃ明显升高（Ｐ＜０．０１），其余脂类水平降低，６月后完全恢复正常；非激素敏感型患儿治疗８周后血脂各项指标与治疗前比较无显著差异，３／６例ＴＣ、ＨＤＬ－Ｃ水平增高持续至１年后。结论肾病患儿脂类代谢异常可持续很长时间并增加肾小球硬化和动脉硬化的危险性，有必要给予非激素敏感型患儿降脂药物治疗
To explore the characteristics of children with nephrotic syndrome dyslipidemia and its relationship with the clinical status and prognosis of nephropathy. Methods The levels of serum lipids, lipoproteins and apolipoproteins in 30 children with nephrotic syndrome were followed up. Results The incidence of nephropathy was significantly higher than that of TC and LDL-C (P <0.05) , P <0.01), with the increase of VLDL-C, TG, apo-B100, LDL-C had no significant change. After 8 weeks of hormone therapy, HDL-C in hormone-sensitive children was significantly higher (P <0.01), and the remaining lipid levels were reduced and returned to normal after 6 months. In the non-hormone sensitive children, the levels of serum lipids There was no significant difference between the index and before treatment, 3/6 cases of TC, HDL-C levels increased to 1 year later. Conclusion The abnormal lipid metabolism in children with renal disease can last a long time and increase the risk of glomerulosclerosis and arteriosclerosis. It is necessary to give lipid-lowering drug therapy in children with non-hormone sensitive