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本实验研究了不同浓度和不同作用时间的去甲肾上腺素（ＮＡ）对大鼠脾脏Ｔ淋巴细胞增殖的影响，并探讨α和β受体在此影响中的作用。结果表明，１０￣（－８）－－１０￣（－５）ｍｏｌ／ＬＮＡ可显著抑制由刀豆素Ａ（ＣｏｎＡ）诱导的Ｔ细胞增殖反应，其中１０￣（－７）ｍｏｌ／ＬＮＡ的抑制作用最强。ＮＡ与已被ＣｏｎＡ刺激ｌｈ的Ｔ细胞作用后，或者ＮＡ与脾细胞作用１ｈ后被洗去，Ｔ细胞的增殖仍受到抑制，但是ＮＡ不能抑制已被Ｃｏｎ Ａ刺激６ｈ的Ｔ细胞的增殖。α受体拮抗剂酚妥拉明（Ｐｈｅｎ，１０￣（－６）ｍｏｌ／Ｌ）和β受体拮抗剂心得安（Ｐｒｏｐ，１０￣（－７）ｍｏｌ／Ｌ）均可完全阻断１０￣（－８）和１０￣（－７）ｍｏｌ／ＬＮＡ的免疫抑制作用。结果提示，ＮＡ具有非浓度依赖性的细胞免疫抑制作用，此作用可能发生于Ｔ细胞激活前或激活早期，并可能通过α和β受体介导。
This study investigated the effects of noradrenaline (NA) at different concentrations and different time periods on the proliferation of T lymphocytes in spleen of rats and the effects of α and β receptors on this effect. The results showed that 10 ~ (-8) -10 ~ (-5) mol / LNA could significantly inhibit the proliferation of T cells stimulated by ConA, and the inhibitory effect of 10 ~ (-7) mol / LNA Most effective After T cells stimulated by Con A for 1 h or NA were washed with splenocytes for 1 h, the proliferation of T cells was still inhibited. However, NA did not inhibit the proliferation of T cells stimulated by Con A for 6 h. α, α -receptor antagonist Phentolamine (Phen, 10 ~ (-6) mol / L) and β receptor antagonist propranolol (Prop, 10 ~ (-7) mol / L) (-8) and 10 ~ (-7) mol / L of immunosuppressive effect. The results suggest that NA has a non-concentration-dependent cellular immunosuppressive effect that may occur before or during T cell activation and may be mediated by alpha and beta receptors.