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用产肠毒素大肠杆菌（ＥＴＥＣ）的４种主要毒力基因（ＬＴ、ＳＴｐ、ＳＴｈ、ＣＦＡ／Ｉ）制成同位素标记的探针作为诊断手段，在广州市远郊农村对ＥＴＥＣ腹泻病做了系列研究。该病年发病率１２．１７％，年龄１个月～７５岁。不足５岁的发病率为８０．２８％，其中不足２岁的高达１８．９７％；５岁以上的为２．１８％，差异非常显著（Ｐ＜０．０１）．男孩显著高于女孩（Ｐ＜０．０１）．发病高峰在７月（１．４７％）和１１月（１．７６％）。临床症状以腹泻（１００％）、呕吐（３２．５％）、食欲差（２８．９％）为主，９５％的不足２岁患者伴有上感症状，３１．３％有３８℃以下低热，个别达３９℃以上者常伴有合并感染，但成人少见，７５％患者为水样便或稀便，１４．５％为粘液便，３．６％为脓血便；有脓血便者常合并志贺氏菌、空肠弯曲菌或侵袭性大肠杆菌（ＥＩＥＣ）感染。８２％的患者每天大便３～５次，＞１０次者常有合并感染。菌型以ＥＴＥＣ－ＳＴｐ为主，依次为ＬＴ、ＳＴ／ＬＴ和ＣＦＡ／Ｉ。病程一般为３～４天。对常用抗菌药物敏感，但对红霉素、四环素、青霉素Ｇ有高度抗性，且多重抗性十分普遍。
The four major virulence genes (LT, STp, STh, CFA / I) of Enterotoxigenic Escherichia coli (ETEC) were used as diagnostic tools for the diagnosis of ETEC diarrhea in rural areas of Guangzhou the study. The disease incidence of 12.17%, age 1 month to 75 years old. The incidence of under 5 years old was 80.28%, of which 18.97% was less than 2 years old and 2.18% over 5 years old, the difference was significant (P <0.01). Boys were significantly higher than girls (P <0.01). The peak incidence in July (1.47%) and November (1.76%). Clinical symptoms were mainly diarrhea (100%), vomiting (32.5%) and poor appetite (28.9%). 95% of patients under 2 years of age had symptoms of upper flu and 31.3% , And those with fever of more than 39 ℃ are often associated with co-infection. However, rare in adults, 75% are watery or loose stools, 14.5% are mucoid stools, and 3.6% are pus and bloody stools. Shigella, Campylobacter jejuni, or invasive Escherichia coli (EIEC) infection. 82% of patients stool 3 to 5 times a day,> 10 times are often complicated by infection. The dominant strains were ETEC-STp, followed by LT, ST / LT and CFA / I. Course of disease is generally 3 to 4 days. It is sensitive to common antibiotics but highly resistant to erythromycin, tetracycline and penicillin G, and multiple resistance is very common.