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目的观察乳糖酸阿奇霉素治疗小儿支气管肺炎的疗效。方法选取我院2012年1月—2013年1月住院支气管肺炎患儿114例,按照随机数字表法分为观察组及对照组,每组57例。对照组患儿给予红霉素15~30 mg·kg-1·d-1静脉滴注,7~10 d后改为红霉素片口服5~7 d;观察组患儿给予乳糖酸阿奇霉素10 mg·kg-1·d-1静脉滴注,5~7 d后改为乳糖酸阿奇霉素片口服3 d。观察两组患儿咳嗽咳痰、气促、肺部啰音消失时间及治疗期间不良反应情况。结果观察组患儿咳嗽咳痰、气促、肺部啰音消失时间均短于对照组(P<0.05)。治疗期间观察组患儿不良反应发生率为14.04%,低于对照组的28.07%(P<0.05)。结论乳糖酸阿奇霉素可有效缓解支气管肺炎患儿临床症状和体征,效果较好,且安全性较高。
Objective To observe the effect of azithromycin lactobionate on bronchial pneumonia in children. Methods A total of 114 hospitalized children with bronchial pneumonia in our hospital from January 2012 to January 2013 were randomly divided into observation group and control group according to random number table method, with 57 cases in each group. The control group received intravenous drip of erythromycin 15 to 30 mg · kg -1 · d -1 and changed to erythromycin 5 to 7 days after 7 to 10 days. The patients in the observation group received azithromycin 10 mg · kg-1 · d-1 intravenous infusion, 5 ~ 7 d later changed to lactose azithromycin tablets orally 3 d. Two groups of children cough and sputum, shortness of breath, disappearance of pulmonary rales and adverse reactions during treatment were observed. Results The cough and sputum, shortness of breath, and the disappearance of pulmonary rales in the observation group were shorter than those in the control group (P <0.05). The incidence of adverse reactions in observation group was 14.04% during treatment period, which was lower than 28.07% in control group (P <0.05). Conclusion Azithromycin lactobionate can effectively relieve the clinical symptoms and signs of children with bronchopneumonia, the effect is better and the safety is higher.