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目的观察含奥沙和铂利羟基喜树碱的联合化疗方案治疗晚期胃癌的近期疗效及不良反应。方法化疗方案(OHLF3方案):奥沙利铂130mg/m2,静滴,第1日:羟基喜树碱6mg/m2,静滴,第1—5日;甲酰四氢叶酸钙200mg/m2,静滴2小时,第1—3日;5—氟脲嘧啶400mg/m2,快速静注,追加600mg/m2,持续静滴22小时,第1—3日,每21日为一周期,完成3周期后判定疗效,有效病例4周后确认。结果全组26例,总有效率(CR+PR)为50%(18/36);主要不良反应为轻度的血液学毒性、恶心呕吐和外周感觉神经异常。结论含奥沙利铂和羟基喜树碱的OHLF3方案是治疗晚期胃癌有效且毒性较小的联合化疗方案。
Objective To observe the short-term curative effect and side effects of combination chemotherapy with oxaliplatin and platinum-hydroxycamptothecin in the treatment of advanced gastric cancer. Methods Chemotherapy regimen (OHLF3 regimen): oxaliplatin 130mg / m2, intravenous infusion, 1st day: HCPT 6mg / m2, intravenous drip, 1st - 5th; Leucovorin 200mg / m2, Intravenous drip for 2 hours, day 1 to 3; 5-fluorouracil 400mg / m2, rapid intravenous injection, additional 600mg / m2, intravenous infusion of 22 hours, 1-3 days, every 21 days for a period of 3 After the cycle to determine the efficacy of valid cases confirmed after 4 weeks. Results The whole group of 26 cases, the total effective rate (CR + PR) was 50% (18/36); the main adverse reactions were mild hematological toxicity, nausea and vomiting and peripheral sensory nerve abnormalities. Conclusion The OHLF3 regimen containing oxaliplatin and hydroxycamptothecin is an effective and less toxic combination chemotherapy for advanced gastric cancer.