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目的探讨骨质疏松高危老年人群骨生化代谢与骨质疏松的关系。方法从社区65岁以上人群健康体检中收集一般资料,应用Cockcroft公式与亚洲人骨质疏松自我筛查工具(OSTA)筛查出内生肌酐清除率轻度减退伴骨质疏松高危人群。应用双能X线吸收仪(DXA)测定左股骨颈骨密度值(LFN BMD),同时测定血生化指标及骨生化、代谢转换指标。结果共筛选出236例骨质疏松高危老年人群,平均年龄为(77.40±5.46)岁。logistic多元回归分析显示OSTA指数、血清25羟维生素D3[25(OH)VitD_3]与骨质疏松呈负相关(OR=0.08,OR=0.65),甲状旁腺激素(PTH)与骨质疏松呈正相关(OR=1.54)。结论 OSTA指数适合运用在社区骨质疏松高危老年人群的筛查工作中,上述人群普遍存在25(OH)VitD_3缺乏,在上述人群中适当补充活性维生素D3和钙剂可延缓骨质疏松的发生。
Objective To investigate the relationship between bone biochemical metabolism and osteoporosis in high-risk senile people with osteoporosis. Methods The general data were collected from the health examination of the population over the age of 65 in the community and screened out the low endogenous creatinine clearance rate and high risk population of osteoporosis using Cockcroft formula and OSTA. Left femur neck bone mineral density (LFN BMD) was measured by dual energy X-ray absorptiometry (DXA), and blood biochemical parameters, bone biochemistry and metabolic conversion indexes were also measured. Results A total of 236 elderly patients at high risk of osteoporosis were screened, with an average age of (77.40 ± 5.46) years. Logistic multivariate regression analysis showed that OSTA, serum 25hydroxyvitamin D3 [25 (OH) VitD_3] were negatively correlated with osteoporosis (OR = 0.08, OR = 0.65) and PTH positively correlated with osteoporosis (OR = 1.54). Conclusion The OSTA index is suitable for the screening of high-risk elderly population with osteoporosis in community. The 25 (OH) VitD_3 deficiency is common in the above-mentioned population. Appropriate supplementation of active vitamin D3 and calcium in these population can delay the occurrence of osteoporosis.