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目的:观察瑞格列奈联合二甲双胍治疗糖尿病的疗效。方法:选取2013年5月至2014年10月我院收治的100例糖尿病患者作为本次的研究对象,随机分为观察组和对照组,每组各50例,对照组30例患者予以服用瑞格列奈,观察组30例患者予以瑞格列奈和二甲双胍联合服用。对比观察二组疗效。结果:治疗后两组糖尿病患者的FPG、2h PG和Hb AIC水平均有所改善,存在显著差异(p<0.05),观察组患者的FPG、2h PG和Hb AIC下降程度明显比对照组大。在治疗期间对两组患者进行观察,均为发现严重的低血糖反应,仅在对照组发现1例轻微低血糖反应,在进食后很快得到缓解,未出现腹胀、腹泻等消化道不良反应。瑞格列奈联合二甲双胍治疗糖尿病效果明显优于单纯使用瑞格列奈治疗效果。结论:瑞格列奈联合二甲双胍治疗糖尿病效果显著,副作用小,患者认可度高,值得临床推广应用。
Objective: To observe the effect of repaglinide combined with metformin in the treatment of diabetes mellitus. Methods: 100 cases of diabetic patients treated in our hospital from May 2013 to October 2014 were randomly divided into observation group and control group, 50 cases in each group and 30 cases in control group Gleevec, the observation group of 30 patients were treated with repaglinide and metformin combination. Comparison of two groups observed efficacy. Results: The levels of FPG, 2h PG and Hb AIC in both groups were improved after treatment, there was a significant difference (p <0.05). The decrease of FPG, 2h PG and Hb AIC in the observation group was obviously more than that in the control group. During the treatment of two groups of patients were observed, were found to be serious hypoglycemic response, only in the control group was found in 1 case of mild hypoglycemia, eased quickly after eating, no abdominal distension, diarrhea and other gastrointestinal adverse reactions. The effect of repaglinide combined with metformin in the treatment of diabetes was significantly better than that of repaglinide alone. Conclusion: The combination of repaglinide and metformin has significant effects in the treatment of diabetes with small side effects and high patient acceptance, which is worthy of clinical application.