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本实验对抗组织胺及抗炎药治疗早期肺水肿的效果进行了观察,实验动物(犬)20只,分四组:致伤对照组(Ⅰ组)、H_1、H_2受体拮抗剂组(Ⅱ组)、消炎痛组(Ⅲ组)、地塞米松组(Ⅳ组)。观察结果表明:肺间质性肺水肿,Ⅱ组最轻,而肺泡性肺水肿Ⅱ、Ⅲ组均较轻,且与Ⅰ组相比较,相差非常显著(P<0.01)。肥大细胞脱颗粒的程度,Ⅰ、Ⅲ、Ⅳ组相似,而Ⅱ组与Ⅰ组比较,Ⅲ级明显减少(P<0.01)。本实验似可以说明:苯海拉明、甲氰脒胍有抑制肥大细胞脱颗粒作用。
The effect of anti-histamine and anti-inflammatory drugs on early pulmonary edema was observed in this experiment. Twenty experimental animals (dogs) were divided into four groups: Injury control group (group I), H_1, H_2 receptor antagonist group (II Group), indomethacin group (Group III), dexamethasone group (Group IV). Observations showed that interstitial pulmonary edema in the lungs was the lightest in the group II and lighter in the alveolar pulmonary edema group II and III. Compared with the group I, the difference was very significant (P<0.01). The degree of degranulation of mast cells was similar in groups I, III, and IV, while it was significantly decreased in group III compared with group I (P<0.01). This experiment seems to indicate that diphenhydramine and guanidine have inhibitory effects on degranulation of mast cells.