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目的探讨流式细胞免疫表型分析(FCI)在实体组织中诊断淋巴组织增生性病变的应用价值。方法采用流式细胞术对261例淋巴组织增生性病变行免疫表型分析,并与病理活检结果进行对比。结果流式细胞免疫表型分析免疫表型分析与病理活检结果比较,差异无统计学意义(P>0.05)。通过流式细胞术诊断非霍奇金淋巴瘤119例,其中B细胞淋巴瘤70例,T细胞淋巴瘤16例,浆细胞肿瘤4例,NK细胞淋巴瘤21例,前体淋巴造血组织肿瘤8例。B细胞淋巴瘤中,以弥漫大B细胞淋巴瘤为多见;T细胞淋巴瘤中,以血管免疫母细胞性T细胞淋巴瘤为多见。FCI与常规病理活检有19例结果不一致。结论本研究结果提示FCI是淋巴组织增生性病变病理诊断的重要辅助手段,可提高诊断的准确性,并可缩短确诊时间,值得推广应用。
Objective To investigate the value of flow cytometric immunophenotyping (FCI) in diagnosing lymphoproliferative lesions in solid tissues. Methods 261 cases of lymphoproliferative lesions by flow cytometry immunohistochemical analysis and pathological biopsy results were compared. Results Flow cytometric analysis of immunophenotyping and pathological biopsy results, the difference was not statistically significant (P> 0.05). 119 cases of non-Hodgkin’s lymphoma were diagnosed by flow cytometry, including 70 cases of B cell lymphoma, 16 cases of T cell lymphoma, 4 cases of plasma cell tumor, 21 cases of NK cell lymphoma, 8 cases of precursor lymphoid hematopoietic tumor 8 example. B-cell lymphoma to diffuse large B-cell lymphoma is more common; T-cell lymphoma, vascular immune blasts of T-cell lymphoma is more common. There were 19 cases of FCI inconsistent with routine biopsy. Conclusion The results of this study suggest that FCI is an important auxiliary pathological diagnosis of lymphoproliferative lesions, which can improve the accuracy of diagnosis and shorten the time of diagnosis. It is worth popularizing and applying.