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目的 :探讨 0 .5mg ml丝裂霉素C (MMC)预防术后翼状胬肉复发中的作用及安全性。方法 :翼状胬肉 30例、37眼术中应用 0 .5mg mlMMC为治疗组 ,以不用MMC的 30例、38眼为对照组。结果 :随访 6～ 2 4个月 ,平均 16 .5个月 ,治疗组治愈 2 9例、36眼 ,复发 1例、1眼 ,复发率为 3.3% ,治愈率为 96 .7% ;对照组治愈 2 2例、30眼 ,复发 8例、8眼 ,复发率为 2 6 .6 7% ,治愈率为 73.33%。两组术后复发率差异有显著性 (P <0 .0 5 )。结论 :在翼状胬肉手术中应用 0 .5mg ml的MMC与传统的治疗方法相比明显降低了术后复发率 ,并避免了对角膜和其它正常眼组织的损伤
Objective: To investigate the role and safety of 0.5 mg mitomycin C (MMC) in preventing postoperative recurrence of pterygium. Methods: 30 cases of pterygium, 37 cases of intraoperative application of 0.5mg mlMMC for the treatment group, without MMC in 30 cases, 38 eyes as the control group. Results: The follow-up ranged from 6 to 24 months, with an average of 16.5 months. The treatment group was 29 cases and 36 eyes were cured. One case had recurrence and the recurrence rate was 3.3%. The cure rate was 96.7% There were 22 cases cured, 30 eyes recurred and 8 cases recurred. The recurrence rate was 26.76% and the cure rate was 73.33%. There was a significant difference in the recurrence rate between the two groups (P <0.05). CONCLUSIONS: The application of MMC at 0.5 mg ml in pterygium surgery significantly reduced the rate of postoperative recurrence compared with conventional treatment and prevented corneal and other normal ocular tissue damage