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作者正在研制一种疟疾DNA疫苗。关键问题之一是用该疫苗在小鼠中获得的免疫原性资料来预测免疫人群的结果的可信度。进行人体试验之前,在非人灵长类动物中确定DNA疫苗的免疫原性和保护性效果是十分必要的,夜猴是评价疟疾DNA疫苗的免疫原性和保护性效果的理想模型。作者曾报道编码约氏疟原虫环子孢子蛋白(PyCSP)的质粒DNA经肌肉免疫小鼠后产生了高水平的抗体反应,在此基础上,再用夜猴来评定该
The author is developing a malaria DNA vaccine. One of the key issues is the use of immunogenicity data obtained from this vaccine in mice to predict the credibility of the results of immunized populations. Before conducting human trials, it is essential to determine the immunogenicity and protective effect of DNA vaccines in nonhuman primates, and the night monkey is an ideal model for evaluating the immunogenicity and protective efficacy of malaria DNA vaccines. The authors have reported that plasmid DNA encoding Plasmodium yoelii circumsporozoite protein (PyCSP) produced a high level of antibody response in muscle-immunized mice, and on the basis of this,