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目的探究免疫疾病中调节性B细胞的调控机制。方法选取78例免疫疾病患者作为观察组,选取78例正常人作为对照组,比较两组研究对象外周血中B10细胞、B10前体细胞的数量以及两组研究对象外周血中B10细胞的功能。结果观察组研究对象外周血中B10细胞数量少于对照组,B10前体细胞的数量多于对照组(P<0.05),且观察组研究对象外周血中B10细胞的功能强于对照组(P<0.05)。结论调节性B细胞对人体具有负向免疫调节作用,其功能失调将可能导致人类多种自身免疫病的发生。
Objective To investigate the regulatory mechanism of regulatory B cells in immune diseases. Methods 78 patients with immune disease were selected as the observation group and 78 healthy individuals were selected as the control group. The numbers of B10 cells, B10 precursor cells in the peripheral blood and the function of B10 cells in the two groups were compared. Results The number of B10 cells in peripheral blood of the observation group was less than that of the control group, and the number of B10 precursor cells was more than that of the control group (P <0.05). The B10 cells in the peripheral blood of the observation group were more effective than the control group <0.05). Conclusion Regulatory B cells have a negative immune regulation effect on human body, and their dysfunction may lead to a variety of autoimmune diseases in humans.