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雄性Wistar大鼠用链脲佐菌素诱导DM模型,将成模大鼠随机分为模型组、糖肾安组、厄贝沙坦组,并设置正常对照组。灌胃8周。结果模型组大鼠尿TGF-β1、UMA高于正常组(104.3±12.5/76.1±6.3,102.4±13.7/72.2±8.2,P<0.01),糖肾安组与厄贝沙坦组大鼠尿TGF-β1、UMA水平较模型组降低(86.3±13.1、81.8±16.5/104.3±12.5,83.3±11.5、81.4±9.4/102.4±13.7,P<0.01),各组大鼠尿TGF-β1、UMA均呈正相关(r=0.842,0.848,0.904,0.885.均P<0.01)。结论通过下调TGF-β1可能是糖肾安煎剂防治DN的机制之一。
Male Wistar rats were induced with streptozotocin to induce DM. The model rats were randomly divided into model group, Tangshenan group and Irbesartan group, and the normal control group was set up. Gavage for 8 weeks. Results The urinary TGF-β1 and UMA were higher in the model group than in the normal group (104.3±12.5/76.1±6.3, 102.4±13.7/72.2±8.2, P<0.01). Rats in the Tangshenan and Irbesartan groups received urine The levels of TGF-β1 and UMA were lower than those in the model group (86.3±13.1, 81.8±16.5/104.3±12.5, 83.3±11.5, 81.4±9.4/102.4±13.7, P<0.01). Rat urine TGF-β1 and UMA in each group All showed positive correlations (r=0.842, 0.848, 0.904, 0.885, all P<0.01). Conclusion The down-regulation of TGF-β1 may be one of the mechanisms of preventing and treating DN by Tang Shen An Decoction.