Antiarthritic effects of Ajuga bracteosa Wall ex Benth.in acute and chronic models of arthritis in a

• 作 者: Gaurav Kaithwas Raju Gautam Sanjay M Jachak Arvind Saklani
• 机 构: Department of Pharmaceutical Sciences,Assam University,Department of Natural Products,National Insti
• 出 处: Asian Pacific Journal of Tropical Biomedicine
• 发表日期: 2012年03期
• 关键词: immunological aspirin formaldehyde adjuvant chemicals inhibiting saline administ

Objective:To evaluate the antiarthritic activity of Ajuga bracteosa using albino rats.Methods: The antiarthritic activity of 70%ethanolic extract of Ajuga bracteosa(EEAB) was evaluated against turpentine oil- and formaldehyde- induced acute non immunological and complete freund’s adjuvant(CFA)-induced chronic immunological arthritis in albino rats.Results:EEAB showed a significant(P<0.05) and dose dependent inhibitory effect against acute and chronic models of arthritis.EEAB exhibited better antiarthritic activity than the standard aspirin.Conclusions: EEAB exhibits a significant and promising antiarthritic activity against acute and chronic arthritis and supports the traditional use of Ajuga bracteosa for rheumatism and other inflammatory diseases.

Objective: To evaluate the antiarthritic activity of Ajuga bracteosa using albino rats. Methods: The antiarthritic activity of 70% ethanolic extract of Ajuga bracteosa (EEAB) was evaluated against turpentine oil- and formaldehyde- induced acute non immunological and complete freund’s adjuvant (CFA) -induced chronic immunological arthritis in albino rats. Results: EEAB showed a significant (P <0.05) and dose dependent inhibitory effect against acute and chronic models of arthritis. EEAB favors antiarthritic activity than the standard aspirin.Conclusions: EEAB exhibits a significant and promising antiarthritic activity against acute and chronic arthritis and supports the traditional use of Ajuga bracteosa for rheumatism and other inflammatory diseases.